IMB Centre for Pain Research

Smith, M, Cabot PJ, Ross FB, Robertson AD and Lewis RJ (2002) The novel N-type calcium channel blocker, AM336, produces potent dose-dependent antinociception after intrathecal dosing in rats and inhibits substance P release in rat spinal cord slices. Pain 96: 119-127.

Nielsen CK, Lewis RJ, Alewood D, Drinkwater R, Palant E, Patterson M, Yaksh TL, McCumber D, Smith MT (2005) Anti-allodynic efficacy of the c-conopeptide, Xen2174, in rats with neuropathic pain. Pain 118:112-124.

Ekberg J, Jayamanne A, Vaughan CW, Aslan S, Thomas L, Mould J, Drinkwater R, Baker MD, Abrahamsen B, Wood JN, Adams DJ, Christie MJ, Lewis RJ (2006) µO-conotoxin MrVIB selectively blocks Nav1.8 sensory neuron specific sodium channels and chronic pain without motor deficits. Proc Natl Acad Sci 103: 17030-17035.

Vetter I, Touska F, Hess A, Hinsbey R, Sattler S, Lampert A, Sergejeva M, Namer B, Sharov A, Collins L, Eberhardt M, Engel M, Cabot PJ, Wood J, Vlachova V, Reeh P, Lewis R, Zimmermann K. (2012) Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling. EMBO Journal 31: 3795-808.

Dantas de Araujo A, Mobli M, Brierley SM, Castro J, Harrington AM, Vetter I, Dekan Z, Muttenthaler M, Wan JJ, Lewis RJ, King GF, Alewood PF (2014) Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal pain. Nature Communications 5: 3165.

Deuis JR, Zimmermann K, Romanovsky AA, Possani LD, Cabot PJ, Lewis RJ, Vetter I. An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Nav1.6 in peripheral pain pathways. Pain. 2013 Sep;154(9):1749-57.

Vetter I, Hein A, Sattler S, Hessler S, Touska F, Bressan E, Parra A, Hager U, Leffler A, Boukalova S, Nissen M, Lewis RJ, Belmonte C, Alzheimer C, Huth T, Vlachova V, Rehh PW, Zimmermann K. Amplified Cold Transduction in Native Nociceptors by M-Channel Inhibition. J Neurosci. 2013 Oct 16;33(42):16627-41.

Vetter I, Touska F, Hess A, Hinsbey R, Sattler S, Lampert A, Sergejeva M, Namer B, Sharov A, Collins L, Eberhardt M, Engel M, Cabot PJ, Wood J, Vlachova V, Reeh P, Lewis R, Zimmermann K. Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling. EMBO J; 2012 Oct 3;31(19):3795-808.

Deuis JR, Lim YL, Rodrigues de Sousa S, Lewis RJ, Alewood PF, Cabot PJ, Vetter I. Analgesic effects of clinically used compounds in novel mouse models of polyneuropathy induced by oxaliplatin and cisplatin. Neuro Oncol. 2014 Apr 8. [Epub ahead of print]

Dantas de Araujo A, Mobli M, Brierley SM, Castro J,  Harrington AM, Vetter I, Dekan Z, Muttenthaler M, Wan JJ, Lewis RJ, King GF, Alewood PF. Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal pain. Nat Commun. 2014 Jan 30;5:3165. 

King GF (ed.) (2014) Venoms to drugs: venoms as a source for the development of human therapeutics, Royal Society of Chemistry, London, UK, in press.

King GF & Vetter I (2014) No gain, no pain: NaV1.7 as an analgesic target. ACS Chemical Neuroscience 5: 749–751.

Clark RJ, Jensen J, Nevin ST, Callaghan BP, Adams DJ, Craik DJ (2010) The engineering of an orally active conotoxin for the treatment of neuropathic pain. Angewandte Chemie 49: 6545-6548.

Daly NL, Craik DJ (2011) Conopeptides as novel options for pain management. Drugs of the Future 36: 25-32.

Craik DJ, Schroeder CI (2013) Peptides from mamba venoms as pain killers. Angewandte Chemie 52: 3071-3073.

Wang CK, King GK, Northfield SE, Ojeda, P Craik DJ. Racemic and quasi-racemic X-ray structures of cyclic disulfide-rich peptide drug scaffolds: looking into the mirror for drug design. Angewandte Chemie (in press).

Dantas de Araujo A, Mobli M, Brierley SM, Castro J,  Harrington AM, Vetter I, Dekan Z, Muttenthaler M, Wan JJ, Lewis RJ, King GF & Alewood PF (2014) Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal pain. Nature Communications 5: 3165.

Simons C, Rash LD, Crawford J, Ma L, Cristofori-Armstrong B, Miller D, Ru K, Baillie GJ, Alanay Y, Jacquinet A, Debray FG, Verloes A, Shen J, Yesil G, Guler S, Yuksel A, Cleary JG, Grimmond SM, McGaughran J, King GF, Gabbett MT & Taft RJ (2014) Mutations in the voltage-gated potassium channel KCNH1 cause Temple–Baraitser syndrome and non-syndromic epilepsy. Nature Genetics, in press.

Yang S, Xiao Y, Kang D, Liu J, Li Y, Undheim EAB, Klint JK, Rong M, Lai R & King GF (2013) Discovery of a selective NaV1.7 blocker from centipede venom with analgesic efficacy exceeding morphine in rodent pain models. Proceedings of the National Academy of Sciences USA 110: 17534–17539.

Follett J, Norwood SJ, Hamilton NA, Mohan M, Kovtun O, Tay S, Zhe Y, Wood SA, Mellick GD, Silburn PA, Collins BM, Bugarcic A, Teasdale RD. (2013) The Vps35 D620N Mutation Linked to Parkinson's Disease Disrupts the Cargo Sorting Function of Retromer. Traffic 15(2): 230-44.

Kerr M, Teasdale RD (2014) Live imaging of endosome dynamics. Seminars In Cell and Developmental Biology 31: 11-19.

Teasdale RD, Collins BC (2012) Insights into the PX (phox-homology) domain and SNX (sorting nexin) protein families: structures, functions and roles in disease. Biochemistry Journal 441: 39-59.  

Yau MK, Liu L, Fairlie DP (2013) Towards drugs for protease-activated receptor 2 (PAR2). Journal of Medicinal Chemistry 56: 7477-7497.

Suen JY, Cotterell A, Lohman RJ, Han A, Yau MK, Liu L, Cooper MA, Vesey DA, Fairlie DP (2014) Pathway selective antagonism of proteinase activated receptor 2. British Journal of Pharmacology 171: 4112-4124.

Reid RC, Yau MK, Singh R, Hamidon JK, Reed AN, Chu P, Suen JY, Stoermer MJ, Blakeney JS, Lim J, Faber JM, Fairlie DP (2013) Downsizing a human inflammatory protein to a small molecule with equal potency and functionality. Nature Communications 4 (2802): 1-9.

Blakeney JS, Reid RC, Le GT, Fairlie DP (2007) Nonpeptidic ligands for peptide-activated G protein-coupled receptors. Chemical Reviews 107: 2960-3041.

Dutertre S, Jin A-H, Vetter I, Hamilton B, Sunagar K, Lavergne V, Dutertre V, Fry BG, Antunes A, Venter DJ, Alewood PF, Lewis RJ (2014) Evolution of separate predation- and defence-evoked venoms in carnivorous cone snails. Nature Communications 5: 3521.

Dantas de Araujo A, Mobli M, Brierley SM, Castro J, Harrington AM, Vetter I, Dekan Z, Muttenthaler M, Wan JJ, Lewis RJ, King GF, Alewood PF (2014) Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal pain. Nature Communications. 2014 5: 3165.

Huang X-C, Xiao X, Zhang Y, Talele TT, Salim A, Chen Z-S, Capon RJ (2014) Lamellarin O, a pyrrole alkaloid from an Australian marine sponge, Ianthella sp., reverses BCRP mediated drug resistance in cancer cells. Marine Drugs 12: 3818-3837.

Balansa W, Islam R, Fontaine F, Piggott AM, Zhang H, Xiao X, Webb TI, Gilbert DF, Lynch JW, Capon RJ (2013) Sesterterpene glycinyl-lactams: a new class of glycine receptor modulator from Australian marine sponges of the genus Psammocinia. Organic and Biomolecular Chemistry 11(28): 4695-4701.